Specific types of HPV are currently implicated as etiologic agents of precursors and cancerous lesions of the uterine cervix. This study used the data gained from one hundred twenty-five women who underwent concurrent Papanicolaou smear,
colposcopic
diagnosis, and cervicovaginal lavage for HPV DNA test at Dysplasia Clinic in Kangnam St. Mary's Hospital. 38 patients had lowgrade squamous intraepithelial lesions (LGSILs) and 34 had highgrade squamous intraepithelial lesions (HGSILs), 24
invasive
cervical cancers, and 29 normal control. Colposcopic features were prospectively recorded by Reid's colposcopic index and then correlated with histopathologic diagnosis. Using the colposcopic index, 86.4 % was correlated with histopathologic
findings.
NDAs extracted from the cervicovaginal lavages were analyzed by polymerase chain reaction (PCR) using the HPV L1 consensus primers. HPV DNA was detested in 79 of 125 women (62.2%). Prevalences of HPV DNA in the patients with LGSIL (71.1%), HGSIL
(76.5%)
and cervix cancer (75.0 %) showed no difference in statistics. Lowrisk oncogenic viruses (HPV6/11) were present in 13.2 % of patients with LGSIL, but none was detected n those with HGSIL and cervix cancer. Intermediaterisk oncogenic viruses
(HPV31/33/35) were detected in 5.3 % of patients with LGSIL, 8.8 % in HGSIL and none in cervix cancer. Prevalence of highrisk oncogenic thpe HPV16/18 was higher in HGSIL (41.2%) and invasive cervical cancer (45.8 %) than those of LGSIL
(15.8
%)
and controls (3.5 %) (p=0.0001).
These date indicate that colposcopic scoring has adjunctive diagnostic role in predicting histology. And, HPV DNAs were found in similar incidence in the various histologic grades of cervical neoplasia. HPV6/11 were detected only in LGSIL and
HPV31/33/35 in LGSIL and HGSIL, but not in invasive cancer. HPV16/18 were the predominant viruses which were detected in HGSIL and invasive cervical cancer.
In conclusizn, a combination of HPV testing and comlposcopic scoring would provide sensitive screening methods for cervical cancer and precancerous lesions. And HPV typing might have prognostic value in the management in the management of
patients
with
HPV related cervical neoplastic lesions.
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